8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl

Base Information

• Chemical Name: 8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl
• CAS No.: 256387-82-3
• Molecular Formula: C₁₃₄H₁₈₈N₆O₄₂S₂
• Molecular Weight: 2619.11
• Mol file: 256387-82-3.mol

Synonyms:8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl

Chemical Property of 8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl

There total 3 articles about 8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(4-thiomethoxyphenyl)boronic acid (98546-51-1) + 64,14-diiodo-63,52,43,32,23,13-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl (256387-79-8) → 84,14-dimethylsulfanyl-73,62,53,42,33,22-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl (256387-82-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; for 18h; Heating;

DOI:10.1021/ol991210n

Reference yield: 31.0%

4,4,5,5-tetramethyl-2-(4-methylsulfanylphenyl)-[1,3,2]-dioxaborolane (190788-58-0) + 64,14-diiodo-63,52,43,32,23,13-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl (256387-79-8) + N-(t-Boc)-2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenylsulfanyl]ethylamine (335629-02-2) → 84,14-dimethylsulfanyl-73,62,53,42,33,22-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl (256387-82-3) + 14-2'-t-Boc-aminoethylthio-84-methylthio-73,62,53,42,33,22-hexa(18-aza-6-N-carbonylmethoxy)-p-octiphenyl (335629-05-5) + C146H210N8O46S2

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; toluene; at 80 ℃; for 21h;

DOI:10.1021/ja003141+

Reference yield:

1-aza-18-crown-6 (33941-15-0) + (C6H3(C6H3)2C6H4SCH3)2(OCH2CO2H)6 → 84,14-dimethylsulfanyl-73,62,53,42,33,22-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl (256387-82-3)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/ol991210n

upstream raw materials:

1-aza-18-crown-6

(4-thiomethoxyphenyl)boronic acid

6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl

4,4,5,5-tetramethyl-2-(4-methylsulfanylphenyl)-[1,3,2]-dioxaborolane