diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate

Base Information

• Chemical Name: diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate
• CAS No.: 79997-20-9
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Mol file: 79997-20-9.mol

Synonyms:diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate

Chemical Property of diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate

There total 3 articles about diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Hydroxy-4,6-dimethyl-5-nitro-isophthalsaeurediethylester (85450-68-6) → diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate (79997-20-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; for 72h;

Reference yield: 40.0%

potassium 2,6-bis(ethoxycarbonyl)-3,5-dimethyl-4-nitrosophenoxide → diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate (79997-20-9)

Guidance literature:

With sodium oxalate; In water; at 60 ℃; for 1h;

DOI:10.1134/S1070428019050269

Reference yield:

diethyl 2-hydroxy-4,6-dimethyl-5-nitrosobenzene-1,3-dicarboxylate (69688-91-1) → diethyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylate (79997-20-9)

Guidance literature:

With 0.5% Pd/C; hydrogen; In ethyl acetate; at 24.84 ℃; Kinetics;

DOI:10.1134/S1070428010040111

upstream raw materials:

2-Hydroxy-4,6-dimethyl-5-nitro-isophthalsaeurediethylester

diethyl 2-hydroxy-4,6-dimethyl-5-nitrosobenzene-1,3-dicarboxylate

Downstream raw materials:

5-(2-Chloracetamido)-2-hydroxy-4,6-dimethyl-isophthalsaeurediethylester