(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

Base Information

Chemical Name:(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane
CAS No.:164106-62-1
Molecular Formula:C₂₆H₃₇N₃O₄
Molecular Weight:455.597
Hs Code.:

(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

Synonyms:(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

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Chemical Property of (1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

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Technology Process of (1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

There total 1 articles about (1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,3S,5S)-3-<1(E)-(1-((triisopropylsilyl)oxy)methyl-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

: 164106-62-1
(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -15 ℃; for 1h;
DOI:10.1021/ja00126a017

Reference yield:

: 164106-62-1
(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

: 152425-17-7
(1S,5R,7R)-4-((2-tert-butoxy)-1(E)-ethylidene)-7-hydroxy-7-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-2-zabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) diisopropylethylamine, MsCl, 2.) LiCl / 1.) CH₂Cl₂, -23 deg C, 1 h, 2.) CH₂Cl₂, DMF, -23 deg C to RT

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 12 h

3: NaH / benzene / 48 h / 100 °C

4: KOH / ethanol; H₂O / 3 h / 70 °C

With potassium hydroxide; sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In ethanol; water; benzene;
DOI:10.1021/ja00126a017

Reference yield:

: 164106-62-1
(1R,3S,5S)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

: 163980-18-5
5-(2-{1-[(1S,5R,7R)-4-[2-tert-Butoxy-eth-(E)-ylidene]-7-hydroxy-2-(2,2,2-trifluoro-acetyl)-2-aza-bicyclo[3.2.1]oct-7-yl]-vinyl}-phenyl)-1,3-dimethyl-[1,3,5]triazinan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) diisopropylethylamine, MsCl, 2.) LiCl / 1.) CH₂Cl₂, -23 deg C, 1 h, 2.) CH₂Cl₂, DMF, -23 deg C to RT

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 12 h

3: NaH / benzene / 48 h / 100 °C

With sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In benzene;
DOI:10.1021/ja00126a017