(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine
CAS No.:1374675-89-4
Molecular Formula:C₁₇H₂₄ClN₃O₂S
Molecular Weight:369.915
Hs Code.:

Synonyms:(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

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Chemical Property of (S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

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Technology Process of (S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

There total 3 articles about (S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374675-88-3
(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-89-4
(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h;

Reference yield:

: 1374675-76-9
(S)-3-(2-Chloro-4-fluoro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-89-4
(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 60 °C

3: trifluoroacetic acid / dichloromethane / 16 h

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1374675-77-0
(S)-3-(2-Chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-89-4
(S)-2-[3-Chloro-4-((S)-pyrrolidine-3-sulfonyl)-phenyl]-octahydro-pyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 60 °C

2: trifluoroacetic acid / dichloromethane / 16 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;