1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Base Information

Chemical Name:1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane
CAS No.:81277-67-0
Molecular Formula:C₂₀H₂₄O₃
Molecular Weight:312.409
Hs Code.:

Synonyms:1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Suppliers and Price of 1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

There total 18 articles about 1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 81277-65-8
1α-ethenyl-4α-hydroxy-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

: 81277-67-0
1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Guidance literature:: With chromic acid; In acetone; at 0 ℃; for 1h;
DOI:10.1021/jo00133a020

Reference yield:

: 61950-54-7
(8aS)-1,1-(1,2-ethylenedioxy)-1,2,3,4,6,7,8,8a-octahydro-8a-methyl-6-oxonaphthalene

: 81277-67-0
1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Guidance literature:: Multi-step reaction with 19 steps

1: 89 percent / H₂ / 10percent palladium on carbon / aq. ethanol / 6 h / 760 Torr / Ambient temperature

2: 79 percent / sodium borohydride / methanol / 1 h / 0 °C

3: 85 percent / pyridine / 16 h / Ambient temperature

4: 96 percent / 5percent aq. hydrochloric acid / acetone / 16 h / Ambient temperature

5: bromine / CHCl₃ / 2 h / 0 °C

6: 97 percent / lithium bromide, lithium carbonate / dimethylformamide / 3.5 h / 125 - 130 °C

7: 1.) sodium amide, 2.) 5percent aq. potassium hydroxide / 1.) ammonia (liquid)/THF, -78 deg C, 2 h, 2.) methanol, room temp., 2 h

8: 90 percent / p-toluenesulfonic acid / benzene / 3 h / Heating

9: 96 percent / sodium / liquid ammonia; tetrahydrofuran; ethanol / 2 h / -78 °C

10: 99 percent / 5percent aq. hydrochloric acid / acetone / 16 h / Ambient temperature

11: pyridinium hydrobromide perbromide / CHCl₃ / 1 h / Ambient temperature

12: 96 percent / lithium bromide, lithium carbonate / dimethylformamide / 14 h / 45 °C

13: 77 percent / 30percent hydrogen peroxide, 10percent aq. sodium hydroxide / methanol / 6 h / Ambient temperature

14: 100 percent / p-toluenesulfonic acid / CH₂Cl₂ / 4 h / Ambient temperature

15: 77 percent / lithium aluminum hydride / tetrahydrofuran / 15 h / Ambient temperature

16: 85 percent / 4-(dimethylamino)pyridine / pyridine / 16 h / Ambient temperature

17: 91 percent / sodium hydride / tetrahydrofuran / 14 h / Heating

18: 97 percent / p-toluenesulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

19: 65 percent / 8 N aq. chromic acid / acetone / 1 h / 0 °C

With hydrogenchloride; dmap; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; dihydrogen peroxide; bromine; pyridinium hydrobromide perbromide; sodium; chromic acid; lithium carbonate; sodium hydride; toluene-4-sulfonic acid; sodium amide; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; ammonia; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00133a020

Reference yield:

: 81277-56-7
(+)-(4aR,6R,8aS)-6α-acetoxy-1,2,3,4,4aβ,5,6,7,8,8a-decahydro-1,1-(1,2-ethylenedioxy)-8aβ-methylnaphthalene

: 81277-67-0
1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methyl-3-oxocyclohexane

Guidance literature:: Multi-step reaction with 16 steps

1: 96 percent / 5percent aq. hydrochloric acid / acetone / 16 h / Ambient temperature

2: bromine / CHCl₃ / 2 h / 0 °C

3: 97 percent / lithium bromide, lithium carbonate / dimethylformamide / 3.5 h / 125 - 130 °C

4: 1.) sodium amide, 2.) 5percent aq. potassium hydroxide / 1.) ammonia (liquid)/THF, -78 deg C, 2 h, 2.) methanol, room temp., 2 h

5: 90 percent / p-toluenesulfonic acid / benzene / 3 h / Heating

6: 96 percent / sodium / liquid ammonia; tetrahydrofuran; ethanol / 2 h / -78 °C

7: 99 percent / 5percent aq. hydrochloric acid / acetone / 16 h / Ambient temperature

8: pyridinium hydrobromide perbromide / CHCl₃ / 1 h / Ambient temperature

9: 96 percent / lithium bromide, lithium carbonate / dimethylformamide / 14 h / 45 °C

10: 77 percent / 30percent hydrogen peroxide, 10percent aq. sodium hydroxide / methanol / 6 h / Ambient temperature

11: 100 percent / p-toluenesulfonic acid / CH₂Cl₂ / 4 h / Ambient temperature

12: 77 percent / lithium aluminum hydride / tetrahydrofuran / 15 h / Ambient temperature

13: 85 percent / 4-(dimethylamino)pyridine / pyridine / 16 h / Ambient temperature

14: 91 percent / sodium hydride / tetrahydrofuran / 14 h / Heating

15: 97 percent / p-toluenesulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

16: 65 percent / 8 N aq. chromic acid / acetone / 1 h / 0 °C

With hydrogenchloride; dmap; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; dihydrogen peroxide; bromine; pyridinium hydrobromide perbromide; sodium; chromic acid; lithium carbonate; sodium hydride; toluene-4-sulfonic acid; sodium amide; lithium bromide; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; ammonia; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00133a020