N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

Base Information

Chemical Name:N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide
CAS No.:128633-04-5
Molecular Formula:C₃₄H₄₃N₇O₆S
Molecular Weight:677.825
Hs Code.:

N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

Synonyms:N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

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Chemical Property of N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

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Technology Process of N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

There total 2 articles about N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Gly-D-Phe-Cys(Acm)-D-Trp-Leu

: 128633-04-5
N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

Guidance literature:: With diphenyl phosphoryl azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 4 ℃; for 72h; Yield given;
DOI:10.1021/jm00171a033

Reference yield:

: 128633-32-9
N-tert-butoxycarbonylglycyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine methyl ester

: 128633-04-5
N-[(2R,5R,8S,14R)-14-Benzyl-5-(1H-indol-3-ylmethyl)-8-isobutyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-ylmethylsulfanylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. NaOH, 2.) HCl, acetic acid

2: diphenyl phosphorazidate, NaHCO₃ / dimethylformamide / 72 h / 4 °C

With hydrogenchloride; sodium hydroxide; diphenyl phosphoryl azide; sodium hydrogencarbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00171a033