(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Base Information

Chemical Name:(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester
CAS No.:161009-78-5
Molecular Formula:C₃₂H₄₂N₂O₇
Molecular Weight:566.695
Hs Code.:

Synonyms:(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

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Chemical Property of (S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

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Technology Process of (S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

There total 2 articles about (S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5545-52-8
Z-D(tBu)-OH

: N-allyl-(S)-phenylalanine

: 161009-78-5
(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1016/0040-4039(94)88485-4

Reference yield:

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 161009-78-5
(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / KOH, NaI, TEBAC / acetonitrile / Ambient temperature

2: 95 percent / DCC / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; dicyclohexyl-carbodiimide; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1016/0040-4039(94)88485-4

Reference yield:

: 161009-78-5
(S)-N-Allyl-3-benzyloxycarbonylamino-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

: (R)-11-((S)-1-Amino-4-guanidino-butyl)-7-((S)-1-carboxy-2-phenyl-ethyl)-3,6-dioxo-12-oxa-1,4,7-triaza-bicyclo[7.2.1]dodecane-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 48 h / 50 °C / 11250900 Torr

2: H₂ / Pd/C / methanol

3: TBTU / dimethylformamide / Ambient temperature; pH=8

4: TFA/phenol/H₂O/HSi(i-C₃H₇)3

With chlorotriisopropylsilane; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; phenol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(94)88485-4