methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336965-81-1
Molecular Formula:C₃₁H₃₆F₃N₃O₂
Molecular Weight:539.641
Hs Code.:

Synonyms:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 7 articles about methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1336965-78-6
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-bromo-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 557-20-0
diethylzinc

: 1336965-81-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; for 2h; Reflux;

Reference yield:

: 20780-74-9
7-bromoisatin

: 1336965-81-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 18 h / Reflux

1.3: pH 4 - 5

2.1: thionyl chloride / 3 h / Reflux

2.2: 18 h / 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 13 h / Reflux

4.1: potassium carbonate / acetonitrile / 3 h / Reflux

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Reflux

With N-Bromosuccinimide; thionyl chloride; potassium carbonate; potassium hydroxide; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; tetrachloromethane; ethanol; water; acetonitrile;

Reference yield:

: 101080-38-0,1191245-18-7
N-(2-bromophenyl)-2-isonitrosoacetanilide

: 1336965-81-1
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-8-ethyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 0.75 h / 65 - 80 °C

1.2: 60 °C

2.1: potassium hydroxide / ethanol; water / 0.25 h

2.2: 18 h / Reflux

2.3: pH 4 - 5

3.1: thionyl chloride / 3 h / Reflux

3.2: 18 h / 20 °C

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 13 h / Reflux

5.1: potassium carbonate / acetonitrile / 3 h / Reflux

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Reflux

With N-Bromosuccinimide; thionyl chloride; sulfuric acid; potassium carbonate; potassium hydroxide; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; tetrachloromethane; ethanol; water; acetonitrile;