4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

Base Information

Chemical Name:4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide
CAS No.:1583276-29-2
Molecular Formula:C₂₀H₂₀F₃NO
Molecular Weight:347.38
Hs Code.:

Synonyms:4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

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Chemical Property of 4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

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Technology Process of 4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

There total 4 articles about 4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1583276-50-9
(1Z,4E)-2,2-dimethyl-1-phenyl-5-(4-(trifluoromethyl)phenyl)pent-4-en-1-one oxime

: 1583276-29-2
4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

Guidance literature:: With potassium phosphate; at 120 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201308617

Reference yield:

: 1583276-63-4
(E)-2,2-dimethyl-1-phenyl-5-(4-(trifluoromethyl)phenyl)pent-4-en-1-one

: 1583276-29-2
4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 80 °C

2: potassium phosphate / 1 h / 120 °C / Inert atmosphere

With pyridine; potassium phosphate; hydroxylamine hydrochloride; In ethanol;
DOI:10.1002/anie.201308617

Reference yield:

: 611-70-1
phenyl isopropyl ketone

: 1583276-29-2
4,4-dimethyl-5-phenyl-2-(4-(trifluoromethyl)benzyl)-3,4-dihydro-2H-pyrrole 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 8 h / Reflux

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 80 °C

3.1: potassium phosphate / 1 h / 120 °C / Inert atmosphere

With pyridine; potassium phosphate; hydroxylamine hydrochloride; sodium hydride; In tetrahydrofuran; ethanol; mineral oil;
DOI:10.1002/anie.201308617