(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

Base Information

Chemical Name:(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol
CAS No.:119244-69-8
Molecular Formula:C₁₄H₂₄OSi
Molecular Weight:236.429
Hs Code.:

Synonyms:(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

Chemical Property:

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Technology Process of (R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

There total 4 articles about (R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 112297-82-2
l-menthyl 2-methyl-2-(trimethylsilyl)-4-phenylbutyrate

: 119244-69-8
(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo00267a031

Reference yield:

: 112297-88-8
l-menthyl (trimethylsilyl)acetate

: 119244-69-8
(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) from -78 deg C to RT, overnight

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) from -78 deg C to RT

3: 81 percent / Dibal-H / CH₂Cl₂; hexane / 1 h / 0 °C

With diisobutylaluminium hydride; lithium diisopropyl amide; In hexane; dichloromethane;
DOI:10.1021/jo00267a031

Reference yield:

: 119244-66-5,119244-67-6
l-menthyl (trimethylsilyl)propanoate

: 119244-69-8
(R)-(-)-2-methyl-2-(trimethylsilyl)-4-phenylbutanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C

2: 81 percent / Dibal-H / CH₂Cl₂; hexane / 1 h / 0 °C

With diisobutylaluminium hydride; lithium diisopropyl amide; In hexane; dichloromethane;
DOI:10.1021/jo00267a031