ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

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Chemical Name:ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate
CAS No.:847671-55-0
Molecular Formula:C₃₂H₃₂N₆O₁₀S
Molecular Weight:692.706
Hs Code.:

ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

Synonyms:ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

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Chemical Property of ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

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Technology Process of ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

There total 6 articles about ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 189365-92-2
4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid

: ethyl (2S)-2-{[(7-amino-2,4-dimethyl-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

: 847671-55-0
ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -10 - 20 ℃; pH=8;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 154365-36-3
3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester

: 847671-55-0
ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / KF / dimethylformamide / 20 - 60 °C

2: 94 percent / NaOH; HCl / dioxane; H₂O / 24 h / 20 °C

3: 92 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

4: 95 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

5: 67 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

With 4-methyl-morpholine; hydrogenchloride; potassium fluoride; sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 386214-81-9
2,4-dimethyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

: 847671-55-0
ethyl (2S)-2-{[(2,4-dimethyl-7-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-{[(4-methylphenyl)sulphonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

2: 95 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

3: 67 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004