Technology Process of (E)-1-(5-((E)-3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4 hydroxyphenyl)prop-2-en-1-one
There total 5 articles about (E)-1-(5-((E)-3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4 hydroxyphenyl)prop-2-en-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / dichloromethane / 2 h / 0 °C / Inert atmosphere
2: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 70 °C / Inert atmosphere
3: ethanol; water / 12 h / 0 - 20 °C / Inert atmosphere
4: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere; Microwave irradiation
5: hydrogenchloride; methanol / water / 6 h / Inert atmosphere
With
hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium hydride; caesium carbonate;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
4: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.12.044
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethanol; water / 12 h / 0 - 20 °C / Inert atmosphere
2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere; Microwave irradiation
3: hydrogenchloride; methanol / water / 6 h / Inert atmosphere
With
hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate;
In
ethanol; water; N,N-dimethyl-formamide;
2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.12.044