(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

Base Information

Chemical Name:(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride
CAS No.:1291077-23-0
Molecular Formula:C₂₄H₂₆N₂O₄*ClH
Molecular Weight:442.942
Hs Code.:

Synonyms:(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

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Technology Process of (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

There total 8 articles about (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1291077-26-3
(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,4'-azepane)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

: 1291077-23-0
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; for 1h;

Reference yield:

: 188975-88-4
tert-butyl 4-oxoazepane-1-carboxylate

: 1291077-23-0
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyrrolidine / methanol / 4 h / 70 °C / Microwave irradiation

2.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

3.1: water; hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

5.1: water; acetic acid; hydrogenchloride / 3 h / 85 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 3 h

6.3: 20 °C

7.1: water; hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

With pyrrolidine; hydrogenchloride; water; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.11.010

Reference yield:

: 1291076-33-9
(±)-6-bromo-4-oxospiro[chromane-2,4'-azepane-6-yl]-1'-carboxylic acid tert-butyl ester

: 1291077-23-0
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: water; hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

4.1: water; acetic acid; hydrogenchloride / 3 h / 85 °C

5.1: triethylamine / dichloromethane / 0 °C

5.2: 3 h

5.3: 20 °C

6.1: water; hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

With hydrogenchloride; water; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.11.010