2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Base Information

Chemical Name:2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide
CAS No.:1025803-39-7
Molecular Formula:C₁₉H₁₅N₅O₂
Molecular Weight:345.36
Hs Code.:

2-(4-amino-3-hydroxy-phenyl)-1<i>H</i>-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Synonyms:2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

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Chemical Property of 2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

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Technology Process of 2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

There total 4 articles about 2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027504-23-9
2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

: 1025803-39-7
2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; at 70 - 90 ℃; for 6h;
DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

: 1025996-25-1
2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid

: 1025803-39-7
2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / dimethylformamide / 3 h / 80 °C

1.2: dimethylformamide / 18 h / Heating

2.1: H₂ / Pd/C / ethanol; dimethylformamide / 6 h / 70 - 90 °C

With hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

: 704-13-2
5-formyl-2-nitrophenol

: 1025803-39-7
2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitrobenzene / 18 h / 155 - 160 °C

2.1: 1,1'-carbonyldiimidazole / dimethylformamide / 3 h / 80 °C

2.2: dimethylformamide / 18 h / Heating

3.1: H₂ / Pd/C / ethanol; dimethylformamide / 6 h / 70 - 90 °C

With hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethanol; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2006.03.014