(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
CAS No.:83624-19-5
Molecular Formula:C₂₅H₃₈NO₅P
Molecular Weight:463.554
Hs Code.:

Synonyms:(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Suppliers and Price of (2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

There total 6 articles about (2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 83624-19-5
(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 18 h / Ambient temperature

2: 91 percent / CH₂Cl₂; trifluoroacetic acid / 18 h

3: H₂ / Pd/C

4: 88 percent / H₂ / platinum oxide / ethanol

5: carbonyldiimidazole, Et₃N / acetonitrile / 48 h / Ambient temperature

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jm00401a014

Reference yield:

: phenylmagnesium bromide

: 83624-19-5
(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 18 h / Ambient temperature

2: 91 percent / CH₂Cl₂; trifluoroacetic acid / 18 h

3: H₂ / Pd/C

4: 88 percent / H₂ / platinum oxide / ethanol

5: carbonyldiimidazole, Et₃N / acetonitrile / 48 h / Ambient temperature

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jm00401a014

Reference yield:

: 82087-66-9
N-(benzyloxycarbonyl)-3,4-dehydro-4-phenyl-L-proline

: 83624-19-5
(2S,4R)-4-Cyclohexyl-1-{2-[ethoxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: 88 percent / H₂ / platinum oxide / ethanol

3: carbonyldiimidazole, Et₃N / acetonitrile / 48 h / Ambient temperature

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; platinum(IV) oxide; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1021/jm00401a014