(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

Base Information

Chemical Name:(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol
CAS No.:916659-49-9
Molecular Formula:C₂₀H₁₈Cl₂O₂
Molecular Weight:361.268
Hs Code.:

Synonyms:(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

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Chemical Property of (1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

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Technology Process of (1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

There total 4 articles about (1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92736-71-5
3,5-Dichloro-2-(3-methyl-but-2-enyloxy)-benzaldehyde

: 536-74-3
phenylacetylene

: (1R)-(-)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

: 916659-49-9
(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

Guidance literature:: phenylacetylene; With triethylamine; zinc trifluoromethanesulfonate; In toluene; for 0.25h;

3,5-Dichloro-2-(3-methyl-but-2-enyloxy)-benzaldehyde; In toluene; Further stages. Title compound not separated from byproducts.;
DOI:10.1055/s-2007-966045

Reference yield:

: 870-63-3
prenyl bromide

: 916659-49-9
(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃; KI / dimethylformamide / 2 h / 20 °C

2: Zn(OTf)2; (1S,2R)-(+)-N-methylephedrine / toluene; triethylamine

With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; potassium carbonate; potassium iodide; In triethylamine; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2006-950205

Reference yield:

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 916659-49-9
(1S)-(+)-1-{2-[(3-methylbut-2-en-1-yl)oxy]-3,5-dichlorophenyl}-3-phenylprop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃; KI / dimethylformamide / 2 h / 20 °C

2: Zn(OTf)2; (1S,2R)-(+)-N-methylephedrine / toluene; triethylamine

With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; potassium carbonate; potassium iodide; In triethylamine; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2006-950205