4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester

Base Information

• Chemical Name: 4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester
• CAS No.: 1187201-07-5
• Molecular Formula: C₂₃H₂₄BrNO₄
• Molecular Weight: 458.352
• Mol file: 1187201-07-5.mol

Synonyms:4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester

Chemical Property of 4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester

There total 1 articles about 4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 2-(bromomethyl)propenoate (4224-69-5) + benzyl chloroformate (501-53-1,94274-21-2) + Allyl-[1-(2-bromo-phenyl)-meth-(E)-ylidene]-amine (206271-34-3) → 4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester (1187201-07-5)

Guidance literature:

benzyl chloroformate; Allyl-[1-(2-bromo-phenyl)-meth-(E)-ylidene]-amine; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

methyl 2-(bromomethyl)propenoate; With zinc; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tet.2009.05.009

Reference yield: 80.0%

4-(allylbenzyloxycarbonylamino)-4-(2-bromophenyl)-2-methylenebutyric acid methyl ester (1187201-07-5) → C21H20BrNO4 (1187201-08-6)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; Inert atmosphere;

DOI:10.1016/j.tet.2009.05.009

upstream raw materials:

methyl 2-(bromomethyl)propenoate

benzyl chloroformate

Allyl-[1-(2-bromo-phenyl)-meth-(E)-ylidene]-amine

Downstream raw materials:

C₂₁H₂₀BrNO₄