2,5-Dimethoxyamphetamine hydrochloride

Base Information

• Chemical Name: 2,5-Dimethoxyamphetamine hydrochloride
• CAS No.: 24973-25-9
• Molecular Formula: C11H17 N O2 . Cl H
• Molecular Weight: 231.722
• Hs Code.: 2922299090
• NSC Number: 367445
• UNII: 9SLP5AXR1F
• DSSTox Substance ID: DTXSID6048886
• Wikidata: Q27273080
• ChEMBL ID: CHEMBL557773
• Mol file: 24973-25-9.mol

Synonyms:1-(2,5-dimethoxyphenyl)-2-aminopropane;2,5-dimethoxyamphetamine;2,5-dimethoxyamphetamine hydrochloride;2,5-dimethoxyamphetamine hydrochloride (+-)-isomer;2,5-dimethoxyamphetamine hydrochloride, (R)-isomer;2,5-dimethoxyamphetamine hydrochloride, (S)-isomer;2,5-dimethoxyamphetamine oxalate(1:1), (+-)-isomer;2,5-dimethoxyamphetamine sulfate(2:1);2,5-dimethoxyamphetamine, (+-)-isomer;2,5-dimethoxyamphetamine, (R)-isomer;2,5-dimethoxyamphetamine, (S)-isomer

Chemical Property of 2,5-Dimethoxyamphetamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00139mmHg at 25°C
• Melting Point: 117.5 °C
• Boiling Point: 296.9°C at 760 mmHg
• Flash Point: 145.2°C
• PSA: 44.48000
• LogP: 3.09580
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 231.1026065
• Heavy Atom Count: 15
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

(+/-)-1-(2,5-DIMETHOXYPHENYL)-2-AMINOPROPANE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 3
• Hazard Codes: 3

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=C(C=CC(=C1)OC)OC)N.Cl

Technology Process of 2,5-Dimethoxyamphetamine hydrochloride

There total 7 articles about 2,5-Dimethoxyamphetamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-trifluoroacetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (111381-04-5) → (+/-)-1-(2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (24973-25-9,16094-57-8)

Guidance literature:

With sodium hydroxide; for 14h; Ambient temperature;

DOI:10.1021/jm00396a003

Reference yield:

1-(2,5-dimethoxy-4-nitrophenyl) propan-2-amine (67460-68-8) → (+/-)-1-(2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (24973-25-9,16094-57-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / 3 h / Ambient temperature

2: 82 percent / H₂ / Pd/C / ethanol / 2 h / Ambient temperature

3: 1.) NaNO₂, HCl / 1.) 0-5 deg C, 30 min, 2.) <5 deg C, 30 min

4: NaI / acetonitrile / 1.) 0 deg C, 30 min, 2.) room temperature, 20 h

5: 65 percent / 15percent NaOH / 14 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium iodide; sodium nitrite; palladium on activated charcoal; In ethanol; acetonitrile;

DOI:10.1021/jm00396a003

Reference yield:

N-[2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethyl]-2,2,2-trifluoro-acetamide (111381-01-2) → (+/-)-1-(2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (24973-25-9,16094-57-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / H₂ / Pd/C / ethanol / 2 h / Ambient temperature

2: 1.) NaNO₂, HCl / 1.) 0-5 deg C, 30 min, 2.) <5 deg C, 30 min

3: NaI / acetonitrile / 1.) 0 deg C, 30 min, 2.) room temperature, 20 h

4: 65 percent / 15percent NaOH / 14 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium iodide; sodium nitrite; palladium on activated charcoal; In ethanol; acetonitrile;

DOI:10.1021/jm00396a003

upstream raw materials:

N-trifluoroacetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

2,5-dimethoxyphenylisopropylamine

1-(2,5-dimethoxy-4-nitrophenyl) propan-2-amine

(+/-)-N-[2-(2,5-dimethoxyphenyl)-1-methylethyl]-2,2,2-trifluoroacetamide