ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

Base Information

Chemical Name:ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate
CAS No.:1332365-13-5
Molecular Formula:C₂₄H₂₇ClN₄O₄
Molecular Weight:470.956
Hs Code.:

Synonyms:ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

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Chemical Property of ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

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Technology Process of ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

There total 8 articles about ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1398512-07-6
C₂₄H₂₉ClN₄O₅

: 1332365-13-5
ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1021/op300345v

Reference yield: 90.0%

: 1398512-07-6
C₂₄H₂₉ClN₄O₅

: 1332365-13-5
ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1332365-13-5
ethyl (1R,3S)-3-[4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenylamino]cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water; dimethyl sulfoxide / 105 °C

1.2: 10 °C

2.1: hydrogenchloride / 2 h / 20 °C

2.2: 10 °C / pH 7 - 8

3.1: hydroxylamine / water; dimethyl sulfoxide / 20 - 50 °C

4.1: Carbonyldiimidazole / acetonitrile

4.2: 0.75 h

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 60 °C

With hydrogenchloride; Carbonyldiimidazole; hydroxylamine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;