C₃₀H₃₄I₂N₄O₇

Base Information

• Chemical Name: C₃₀H₃₄I₂N₄O₇
• CAS No.: 1408097-82-4
• Molecular Formula: C₃₀H₃₄I₂N₄O₇
• Molecular Weight: 816.432
• Mol file: 1408097-82-4.mol

Synonyms:C₃₀H₃₄I₂N₄O₇

Chemical Property of C₃₀H₃₄I₂N₄O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₄I₂N₄O₇

There total 4 articles about C₃₀H₃₄I₂N₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C17H21IN2O5 (1408097-81-3) + C13H15IN2O3 (1408097-80-2) → C30H34I2N4O7 (1408097-82-4)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

DOI:10.1039/c2ob26132d

Reference yield:

methyl 2-amino-5-iodobenzoate (77317-55-6) → C30H34I2N4O7 (1408097-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 51 h / 0 - 20 °C / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c2ob26132d

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C30H34I2N4O7 (1408097-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 51 h / 0 - 20 °C / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c2ob26132d

upstream raw materials:

(S)-tert-butyl-2-(4-iodo-2-(methoxycarbonyl)phenylcarbamoyl)pyrrolidine-1-carboxylate

1-(tert-butoxycarbonyl)-L-proline

methyl 2-amino-5-iodobenzoate

C₁₇H₂₁IN₂O₅

Downstream raw materials:

C₂₅H₂₆I₂N₄O₅

C₂₉H₃₂I₂N₄O₇

C₅₄H₅₆I₄N₈O₁₁

C₄₉H₄₈I₄N₈O₉