4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 597533-27-2
• Molecular Formula: C₁₈H₁₄ClN₃O₅
• Molecular Weight: 387.779
• Mol file: 597533-27-2.mol

Synonyms:4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property of 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

There total 3 articles about 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Chloro-2-nitrobenzaldehyde (5551-11-1) + 4-methoxy-3-methylbenzofuran-2-carboxylic acid hydrazide (597533-17-0) → 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (597533-27-2)

Guidance literature:

With sulfuric acid; In methanol; at 20 ℃;

DOI:10.1002/jhet.5570400305

Reference yield:

ethyl 3-Methyl-4-methoxybenzofuran-2-carboxylate (3781-71-3) → 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (597533-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 20 °C

2: 75 percent / sulfuric acid / methanol / 20 °C

With sulfuric acid; hydrazine hydrate; In methanol;

DOI:10.1002/jhet.5570400305

Reference yield:

4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (3781-69-9) → 4-Methoxy-3-methyl-benzofuran-2-carboxylic acid [1-(4-chloro-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (597533-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / potassium carbonate / acetone / 10 h / Heating

2: hydrazine hydrate / methanol / 20 °C

3: 75 percent / sulfuric acid / methanol / 20 °C

With sulfuric acid; potassium carbonate; hydrazine hydrate; In methanol; acetone;

DOI:10.1002/jhet.5570400305

upstream raw materials:

4-Chloro-2-nitrobenzaldehyde

4-methoxy-3-methylbenzofuran-2-carboxylic acid hydrazide

ethyl 3-Methyl-4-methoxybenzofuran-2-carboxylate

4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester