Technology Process of 1-benzyl-6-butyl-2,3-diethyl-4,5-dimethyl-1,2-dihydropyridine
There total 2 articles about 1-benzyl-6-butyl-2,3-diethyl-4,5-dimethyl-1,2-dihydropyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere; Glovebox
1.2: 0.33 h / 20 - 50 °C / Inert atmosphere; Glovebox
2.1: chlorobis(cyclooctene)rhodium(I) dimer; diethyl-{4-dimethylamino-phenyl}-phosphine / toluene / 2 h / 75 °C / Inert atmosphere; Glovebox
With
titanium(IV) tetraethanolate; chlorobis(cyclooctene)rhodium(I) dimer; diethyl-{4-dimethylamino-phenyl}-phosphine;
In
tetrahydrofuran; toluene;
DOI:10.1021/ol303040r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere; Glovebox
1.2: 0.33 h / 20 - 50 °C / Inert atmosphere; Glovebox
2.1: chlorobis(cyclooctene)rhodium(I) dimer; diethyl-{4-dimethylamino-phenyl}-phosphine / toluene / 2 h / 75 °C / Inert atmosphere; Glovebox
With
titanium(IV) tetraethanolate; chlorobis(cyclooctene)rhodium(I) dimer; diethyl-{4-dimethylamino-phenyl}-phosphine;
In
tetrahydrofuran; toluene;
DOI:10.1021/ol303040r
- Guidance literature:
-
With
zinc(II) chloride;
In
neat (no solvent);
at 105 ℃;
for 48h;
diastereoselective reaction;
Inert atmosphere;
Glovebox;
DOI:10.1021/ol303040r
