N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1318754-65-2
Molecular Formula:C₁₈H₁₇F₃N₄OS
Molecular Weight:394.42
Hs Code.:

Synonyms:N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

There total 9 articles about N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1318754-61-8
N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl}benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

: 1318754-65-2
N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl}benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide; With triethylsilane; trifluoroacetic acid; at 50 ℃; for 6h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 2003-14-7
(3-trifluoromethyl-phenyl)-acetyl chloride

: 1318754-65-2
N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: Lawessons reagent / toluene / 6 h / 80 °C

3.1: N,N-dimethyl acetamide / 3 h / 80 °C

4.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

5.1: Dess-Martin periodane / acetonitrile; tetrahydrofuran / 0 - 20 °C

6.1: tetrahydrofuran / 1 h / 0 °C

7.1: trifluoroacetic acid; triethylsilane / 6 h / 50 °C

With Lawessons reagent; triethylsilane; sodium dithionite; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl acetamide; water; toluene; acetonitrile;

Reference yield:

: 84547-59-1
2-methyl-2H-pyrazole-3-carbonyl chloride

: 1318754-65-2
N-{4-ethyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl acetamide / 3 h / 80 °C

2: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

3: Dess-Martin periodane / acetonitrile; tetrahydrofuran / 0 - 20 °C

4: tetrahydrofuran / 1 h / 0 °C

5: trifluoroacetic acid; triethylsilane / 6 h / 50 °C

With triethylsilane; diisobutylaluminium hydride; Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl acetamide; toluene; acetonitrile;