N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Base Information

• Chemical Name: N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine
• CAS No.: 1001014-50-1
• Molecular Formula: C₂₄H₂₀N₆S
• Molecular Weight: 424.529

Synonyms:N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Chemical Property of N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Chemical Property:

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Technology Process of N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

There total 6 articles about N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine (1001014-49-8) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-50-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 1.5h; under 2327.23 Torr;

Reference yield:

5-Amino-2-methylpyridine (80287-53-2,3430-14-6) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-50-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.1: trichlorophosphate / 18 h / 105 °C

2.2: 1.75 h / 0 - 20 °C

3.1: sodium hydrogencarbonate / isopropyl alcohol / Heating / reflux

3.2: 0.33 h / 70 °C

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 145 °C / Microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 2327.23 Torr

With hydrogen; sodium hydrogencarbonate; caesium carbonate; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

4-iodo-N-(6-methylpyridin-3-yl)benzamide (1001013-82-6) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-50-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / 18 h / 105 °C

1.2: 1.75 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / isopropyl alcohol / Heating / reflux

2.2: 0.33 h / 70 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 145 °C / Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 2327.23 Torr

With hydrogen; sodium hydrogencarbonate; caesium carbonate; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; isopropyl alcohol;

upstream raw materials:

N-(4-(1-(6-methylpyridin-3-yl)-4-(thiophen-2-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine

5-Amino-2-methylpyridine

4-iodo-N-(6-methylpyridin-3-yl)benzamide

(E)-4-iodo-N'-(6-methylpyridin-3-yl)benzamidine

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