(2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one

Base Information

• Chemical Name: (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one
• CAS No.: 1168016-44-1
• Molecular Formula: C₁₄H₁₅F₃O₂
• Molecular Weight: 272.267
• Mol file: 1168016-44-1.mol

Synonyms:(2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one

Chemical Property of (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one

There total 6 articles about (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Trifluoromethylbenzaldehyde (447-61-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one (1168016-44-1)

Guidance literature:

With C₁₉H₂₈N₂O₁₀; In neat (no solvent); at -20 ℃; enantioselective reaction;

DOI:10.1055/s-0035-1560701

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one (1168016-44-1) + 2-[(4-trifluoromethylphenyl)(hydroxy)methyl]cyclohexanone

Guidance literature:

With C₂₇H₄₀N₅O₄⁽¹⁺⁾*F₆P^(1-); In water; at 20 ℃; for 20h; stereoselective reaction;

DOI:10.1016/j.mencom.2016.09.007

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (2S,1′R)-2-(hydroxyl-(o-trifluoromethylphenyl)methyl)cyclohexan-1-one (1168016-44-1) + (1S,2R)-2-(hydroxy-(o-(trifluoromethyl)phenyl)methyl)cyclohexan-1-one (1314918-75-6) + 2-(hydroxy-(o-(trifluoromethyl)phenyl)methyl)cyclohexan-1-one

Guidance literature:

With C₂₉H₄₀N₅O₃P; benzoic acid; In water; at 3 ℃; for 96h; Reagent/catalyst; Overall yield = 72 %;

DOI:10.1055/s-0036-1592005

upstream raw materials:

2-Trifluoromethylbenzaldehyde

cyclohexanone