5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole
• CAS No.: 1073828-65-5
• Molecular Formula: C₃₁H₃₈N₄O₄SSi
• Molecular Weight: 590.819
• Mol file: 1073828-65-5.mol

Synonyms:5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

Chemical Property of 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

There total 1 articles about 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylthio)-1-phenyl-1H-tetrazole (1073828-64-4) → 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole (1073828-65-5)

Guidance literature:

With ammonium molybdate-tetrahydrate; dihydrogen peroxide; In ethanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol801923y

Reference yield: 78.0%

C6H9BrO (1073828-58-6) + 5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole (1073828-65-5) → (2S,5S)-2-[(2E,3R)-5-bromo-3-methyl-1,5-hexadienyl]-5-[(3-tert-butyldiphenylsilyloxy)propyl]tetrahydrofuran (1073828-69-9)

Guidance literature:

With potassium hexamethylsilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at -78 - 20 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol801923y

Reference yield:

5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole (1073828-65-5) → 5-(((2S,5R)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole (1073828-81-5)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801923y

upstream raw materials:

5-(((2S,5S)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylthio)-1-phenyl-1H-tetrazole

Downstream raw materials:

5-(((2S,5R)-5-(3-(tert-butyldiphenylsilyloxy)propyl)oxolan-2-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

(2S,5S)-2-[(2E,3R)-5-bromo-3-methyl-1,5-hexadienyl]-5-[(3-tert-butyldiphenylsilyloxy)propyl]tetrahydrofuran