(Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide

Base Information

• Chemical Name: (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide
• CAS No.: 1334840-64-0
• Molecular Formula: C₁₅H₁₇N₃O
• Molecular Weight: 255.319
• Mol file: 1334840-64-0.mol

Synonyms:(Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide

Chemical Property of (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide

There total 2 articles about (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(Z)-N-hydroxypyridine-3-carboximidoyl chloride hydrochloride (195863-43-5) + N-Methyl-N-phenethylamine (589-08-2) → (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide (1334840-64-0)

Guidance literature:

In methanol; at 0 ℃;

DOI:10.1007/s11172-011-0081-3

Reference yield:

3-pyridinealdoxime (87641-61-0) → (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide (1334840-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorine / methanol / 0.25 h / 5 - 10 °C

2: methanol / 0 °C

With chlorine; In methanol;

DOI:10.1007/s11172-011-0081-3

Reference yield: 68.0%

(Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide (1334840-64-0) + dimethyl sulfate (77-78-1) → (Z)-N'-methoxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide (1334840-74-2)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 6h;

DOI:10.1007/s11172-011-0081-3

upstream raw materials:

(Z)-N-hydroxypyridine-3-carboximidoyl chloride hydrochloride

N-Methyl-N-phenethylamine

3-pyridinealdoxime

Downstream raw materials:

(Z)-N'-methoxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide