N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

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Chemical Name:N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide
CAS No.:916051-72-4
Molecular Formula:C₂₆H₁₉ClN₄O₃S₂
Molecular Weight:535.047
Hs Code.:

Synonyms:N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

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Chemical Property of N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

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Technology Process of N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

There total 7 articles about N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 4113-04-6
quinoline-6-carbaldehyde

: 916050-65-2
2-[(5-amino-2-chlorophenyl)amino]-1,3-thiazol-4(5H)-one

: 916051-72-4
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

Guidance literature:: 2-[(5-amino-2-chlorophenyl)amino]-1,3-thiazol-4(5H)-one; benzenesulfonyl chloride; With 1,4-diaza-bicyclo[2.2.2]octane; In 1,4-dioxane; for 1h;

quinoline-6-carbaldehyde; With piperidine; In ethanol; at 150 ℃; for 0.333333h; Microwave heating;

With hydrogenchloride; In ethanol; water; Acidic conditions;

Reference yield:

: 701294-30-6
2-[(2-chloro-5-nitrophenyl)amino]-1,3-thiazol-4(5H)-one

: 916051-72-4
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 760.05 Torr

2.1: 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 1 h

2.2: 0.33 h / 150 °C / Microwave heating

2.3: Acidic conditions

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol;

Reference yield:

: 341036-39-3
2-chloro-5-nitrophenylthiourea

: 916051-72-4
N-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-1-phenylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 130 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 760.05 Torr

3.1: 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 1 h

3.2: 0.33 h / 150 °C / Microwave heating

3.3: Acidic conditions

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol;