5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

Base Information

• Chemical Name: 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide
• CAS No.: 1449332-79-9
• Molecular Formula: C₃₃H₂₅F₂N₅O₃
• Molecular Weight: 577.59
• Mol file: 1449332-79-9.mol

Synonyms:5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

Chemical Property of 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

There total 11 articles about 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.6%

2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-1H-imidazole (1449332-88-0) + 2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (1449332-83-5) → 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide (1449332-79-9)

Guidance literature:

With palladium diacetate; sodium carbonate; XPhos; In 1,4-dioxane; water; at 90 ℃; Sealed tube; Inert atmosphere;

Reference yield:

5-iodo-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide (1449332-82-4) → 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide (1449332-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C

2: sodium carbonate; palladium diacetate; XPhos / 1,4-dioxane; water / 90 °C / Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; sodium carbonate; XPhos; In 1,4-dioxane; water;

Reference yield:

5-iodo-2-methoxy-4-methylbenzoic acid (1241674-09-8) → 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide (1449332-79-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C

3: sodium carbonate; palladium diacetate; XPhos / 1,4-dioxane; water / 90 °C / Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

5-iodo-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

5-iodo-2-methoxy-4-methylbenzoic acid

2-(5-chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-yl)-1H-imidazole

2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide