(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

Base Information

Chemical Name:(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate
CAS No.:372147-63-2
Molecular Formula:C₃₀H₂₆N₃O₂P
Molecular Weight:491.529
Hs Code.:

Synonyms:(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

Chemical Property:

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Technology Process of (Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

There total 5 articles about (Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 603-35-0
triphenylphosphine

: 372147-52-9
ethyl α-azido-β-(imidazo[1,2-a]pyridin-8-yl)propenoate

: 372147-63-2
(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo015582x

Reference yield:

: 13362-26-0
2-aminopyridine-3-carboxylic acid ethyl ester

: 372147-63-2
(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / NaHCO₃ / ethanol; H₂O / 9 h / Heating

2: 21 percent / DIBALH / CH₂Cl₂ / 3 h / -70 °C

3: 10 percent / NaOEt / ethanol / 3 h / -30 - 20 °C

4: 95 percent / CH₂Cl₂ / 12 h / 20 °C

With sodium ethanolate; diisobutylaluminium hydride; sodium hydrogencarbonate; In ethanol; dichloromethane; water; 4: Staudinger reaction;
DOI:10.1021/jo015582x

Reference yield:

: 158020-74-7
imidazo[1,2-a]pyridine-8-carboxylic acid ethyl ester

: 372147-63-2
(Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 21 percent / DIBALH / CH₂Cl₂ / 3 h / -70 °C

2: 10 percent / NaOEt / ethanol / 3 h / -30 - 20 °C

3: 95 percent / CH₂Cl₂ / 12 h / 20 °C

With sodium ethanolate; diisobutylaluminium hydride; In ethanol; dichloromethane; 3: Staudinger reaction;
DOI:10.1021/jo015582x