11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

Base Information

Chemical Name:11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one
CAS No.:1391978-87-2
Molecular Formula:C₂₁H₂₃N₃O₄
Molecular Weight:381.431
Hs Code.:

Synonyms:11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

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Chemical Property of 11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

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Technology Process of 11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

There total 7 articles about 11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1391978-99-6
2-((2-azidoethyl)(4-methoxybenzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

: 1391978-87-2
11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

Guidance literature:: With tributylphosphine; In chlorobenzene; at 180 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1039/c2ob25353d

Reference yield:

: 1391978-98-5
2'-((2-azidoethyl)(4-methoxybenzyl)amino)-1'H-spiro[[1,3]dithiane-2,4'-isoquinoline]-1',3'(2'H)-dione

: 1391978-87-2
11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / 0.25 h / 23 °C / Inert atmosphere

2: tributylphosphine / chlorobenzene / 0.33 h / 180 °C / Inert atmosphere; Microwave irradiation

With tributylphosphine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In chlorobenzene; 2: Staudinger-aza-Wittig reaction;
DOI:10.1039/c2ob25353d

Reference yield:

: 1391978-83-8
1-(2-azidoethyl)-1-[(4-methoxyphenyl)methyl]hydrazine

: 1391978-87-2
11,11-dimethoxy-4-(4-methoxybenzyl)-3,4-dihydro-2H-[1,2,4]triazino[2,3-b]isoquinolin-6(11H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

2: 2-Picolinic acid; copper(l) iodide; caesium carbonate / 1,4-dioxane / 3 h / 70 °C / Inert atmosphere

3: toluene-4-sulfonic acid / water; toluene / 20 h / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 21 h / 25 °C / Inert atmosphere

5: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / 0.25 h / 23 °C / Inert atmosphere

6: tributylphosphine / chlorobenzene / 0.33 h / 180 °C / Inert atmosphere; Microwave irradiation

With 2-Picolinic acid; copper(l) iodide; tributylphosphine; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In 1,4-dioxane; dichloromethane; water; chlorobenzene; toluene; 6: Staudinger-aza-Wittig reaction;
DOI:10.1039/c2ob25353d