Technology Process of 6-cyclopropyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole
There total 7 articles about 6-cyclopropyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol;
at 20 ℃;
DOI:10.1021/jm401986p
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium acetate; 18-crown-6 ether / dichloromethane / 1 h / 20 °C
2: toluene-4-sulfonic acid / chloroform / 20 - 50 °C
3: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 120 °C / Microwave irradiation
4: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere
5: potassium carbonate / tetrahydrofuran / 0.4 h / 120 °C / Microwave irradiation
6: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 1 h / 100 °C / Microwave irradiation
7: hydrogenchloride / methanol; 1,4-dioxane / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); 18-crown-6 ether; potassium acetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; 1-dodecylthiol;
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water;
3: |Suzuki Coupling / 6: |Suzuki Coupling;
DOI:10.1021/jm401986p
- Guidance literature:
-
Multi-step reaction with 8 steps
1: dichloromethane / -78 - 20 °C / Inert atmosphere
2: potassium acetate; 18-crown-6 ether / dichloromethane / 1 h / 20 °C
3: toluene-4-sulfonic acid / chloroform / 20 - 50 °C
4: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 120 °C / Microwave irradiation
5: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere
6: potassium carbonate / tetrahydrofuran / 0.4 h / 120 °C / Microwave irradiation
7: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 1 h / 100 °C / Microwave irradiation
8: hydrogenchloride / methanol; 1,4-dioxane / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); 18-crown-6 ether; potassium acetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; 1-dodecylthiol;
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water;
4: |Suzuki Coupling / 7: |Suzuki Coupling;
DOI:10.1021/jm401986p
