4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Base Information

Chemical Name:4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide
CAS No.:1244968-10-2
Molecular Formula:C₂₈H₃₈N₆O₄
Molecular Weight:522.648
Hs Code.:

Synonyms:4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

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Chemical Property of 4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

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Technology Process of 4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

There total 3 articles about 4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 4778-76-1
N-ethyl pyrrole-2-carboxylic acid

: 1244968-56-6
N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

: 1244968-10-2
4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

Reference yield:

: 1244968-55-5
C₂₉H₃₇N₅O₅

: 1244968-10-2
4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 60 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1175959-17-7
C₁₆H₂₃N₃O₂

: 1244968-10-2
4-((1-ethylpyrrol-2-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.5 h / -30 °C

1.2: 17 h / 20 - 60 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 60 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;