(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Base Information

Chemical Name:(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone
CAS No.:1374636-95-9
Molecular Formula:C₁₇H₁₃FO₃S
Molecular Weight:316.353
Hs Code.:

Synonyms:(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Suppliers and Price of (4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Chemical Property:

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Technology Process of (4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

There total 5 articles about (4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1374636-89-1
(4-fluorophenyl)(6-methoxy-3-(((triisopropylsilyl)oxy)methyl)benzo[b]thiophen-2-yl)methanone

: 1374636-95-9
(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201106734

Reference yield:

: 4897-68-1
2-iodo-4-methoxybromobenzene

: 1374636-95-9
(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: TurboGrignard / -80 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere

2.1: iodine / dichloromethane / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere

3.2: -50 - 20 °C / Inert atmosphere

4.1: TurboGrignard / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

4.2: 1 h / 0 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With TurboGrignard; tetrabutyl ammonium fluoride; iodine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201106734

Reference yield:

: 1374636-44-8
1,2-bis(2-bromo-5-methoxyphenyl)disulfane

: 1374636-95-9
(4-fluorophenyl)(3-(hydroxymethyl)-6-methoxybenzo[b]thiophen-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine / dichloromethane / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere

2.2: -50 - 20 °C / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With TurboGrignard; tetrabutyl ammonium fluoride; iodine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201106734