(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

Base Information

Chemical Name:(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane
CAS No.:220482-19-9
Molecular Formula:C₃₄H₃₆Br₂O₆
Molecular Weight:700.464
Hs Code.:

Synonyms:(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

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Chemical Property of (2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

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Technology Process of (2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

There total 9 articles about (2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 34132-31-5
2-bromo-3-hydroxy-5-methoxytoluene

: 220482-17-7
(-)-(2S,3R)-1,4-bis(benzyloxy)-3-(2-bromo-3-methoxy-5-methylphenyl)oxybutan-2-ol

: 220482-19-9
(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

Guidance literature:: With tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 48h;
DOI:10.1039/a808146h

Reference yield:

: 17401-06-8
(2S,3S)-1,4-bis(benzyloxy)-2,3-butanediol

: 220482-19-9
(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / imidazole / dimethylformamide / 15 h / 20 °C

2: 68 percent / Bu₃P; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

3: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: 45 percent / Bu₃P; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C

With 1H-imidazole; tributylphosphine; tetrabutyl ammonium fluoride; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction / 4: Mitsunobu reaction;
DOI:10.1071/CH99134

Reference yield:

: 36661-64-0
2-bromo-3-methoxy-5-methylphenol

: 220482-19-9
(2R,3R)-1,4-bis(benzyloxy)-2-(2-bromo-3-methoxy-5-methylphenyl)oxy-3-(2'-bromo-5'-methoxy-3'-methylphenyl)oxybutane

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / Bu₃P; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

2: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: 45 percent / Bu₃P; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C

With tributylphosphine; tetrabutyl ammonium fluoride; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu reaction / 3: Mitsunobu reaction;
DOI:10.1071/CH99134