5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide
CAS No.:1609467-83-5
Molecular Formula:C₂₂H₂₅N₅O
Molecular Weight:375.473
Hs Code.:

Synonyms:5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

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Chemical Property of 5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

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Technology Process of 5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

There total 6 articles about 5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609467-82-4
benzyl 3-(5-amino-3-(4-benzylphenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1609467-83-5
5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: With water; sodium hydroxide; In ethanol; at 145 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1609467-76-6
2-((4-iodophenyl)(methoxy)methylene)malononitrile

: 1609467-83-5
5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 2-(methoxy(3-iodo)methylene)-malononitrile / ethanol / 16 h / 20 - 80 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: water; sodium hydroxide / ethanol / 1 h / 145 °C / Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(methoxy(3-iodo)methylene)-malononitrile; water; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1609467-83-5
5-amino-3-(4-benzylphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 16 h / 0 - 80 °C

3.1: triethylamine; 2-(methoxy(3-iodo)methylene)-malononitrile / ethanol / 16 h / 20 - 80 °C

4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: water; sodium hydroxide / ethanol / 1 h / 145 °C / Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(methoxy(3-iodo)methylene)-malononitrile; water; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;