p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

Base Information

Chemical Name:p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside
CAS No.:1415218-25-5
Molecular Formula:C₆₃H₆₇N₃O₁₀SSi
Molecular Weight:1086.39
Hs Code.:

Synonyms:p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

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Chemical Property of p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

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Technology Process of p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

There total 5 articles about p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1415218-24-4
p-tolyl-2-azido-3,6-di-O-benzyl-4-O-t-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-1-thio-β-D-glucopyranoside

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1415218-25-5
p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201205601

Reference yield:

: 1242437-12-2
p-tolyl 2-azido-3,6-di-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-1-thio-β-D-glucopyranoside

: 1415218-25-5
p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 2 h / -78 - 0 °C / Inert atmosphere

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 20 °C / Inert atmosphere

3.1: pyridine hydrogenfluoride / 0 °C / Inert atmosphere

4.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

With 1H-imidazole; silver trifluoromethanesulfonate; pyridine hydrogenfluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; water;
DOI:10.1002/anie.201205601

Reference yield:

: 929040-60-8
p-tolyl 2-O-benzoyl-3-O-benzyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

: 1415218-25-5
p-tolyl 2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→4)-2-O-benzoyl-3-O-benzyl-6-O-tert-butyl-diphenylsilyl-1-thio-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver trifluoromethanesulfonate / dichloromethane; diethyl ether / 0.08 h / -78 °C / Inert atmosphere; Molecular sieve

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 2 h / -78 - 0 °C / Inert atmosphere

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 20 °C / Inert atmosphere

3.1: pyridine hydrogenfluoride / 0 °C / Inert atmosphere

4.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

With 1H-imidazole; silver trifluoromethanesulfonate; pyridine hydrogenfluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; water;
DOI:10.1002/anie.201205601