Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

Base Information

Chemical Name:Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester
CAS No.:210578-21-5
Molecular Formula:C₂₆H₂₃NO₅
Molecular Weight:429.472
Hs Code.:

Synonyms:Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

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Chemical Property of Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

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Technology Process of Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

There total 3 articles about Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5728-52-9
(4-biphenylyl)acetic acid

: 161518-24-7
3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione

: 210578-21-5
Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/jm970744w

Reference yield:

: 205177-88-4
5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indole-3-carboxylic acid ethyl ester

: 210578-21-5
Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. sodium dithionite / CHCl₃; ethanol

2: DIBAL-H / CH₂Cl₂ / 2 h / -30 °C

3: 87 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 50 °C

With sodium dithionite; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm970744w

Reference yield:

: ethyl 4,7-dihydroxy-5-methoxy-1,2-dimethylindole-3-carboxylate

: 210578-21-5
Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL-H / CH₂Cl₂ / 2 h / -30 °C

2: 87 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 50 °C

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970744w