2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile

Base Information

• Chemical Name: 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile
• CAS No.: 350987-55-2
• Molecular Formula: C₁₅H₁₁N₃OS₂
• Molecular Weight: 313.404
• Mol file: 350987-55-2.mol

Synonyms:2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile

Chemical Property of 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile

There total 2 articles about 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

benzyl chloride (100-44-7) + methyl 3-[3-(cyanomethyl)thioureido]thiophene-2-carboxylate (350494-55-2) → 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile (350987-55-2)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 24h;

DOI:10.1002/jhet.5570380217

Reference yield:

3-isothiocyanato-2-thiophenecarboxylic acid methyl ester (81321-10-0) → 2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile (350987-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃N / dimethylformamide / 2 h / 20 °C

2: 71 percent / aq. NaOH / acetone / 24 h / 20 °C

With sodium hydroxide; triethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.1002/jhet.5570380217

Reference yield: 76.0%

2-(benzylthio)-4-oxothieno[3,2-d]pyrimidine-3(4H)acetonitrile (350987-55-2) → 6-amino-5-(2-benzylsulfanyl-4-oxo-4H-thieno[3,2-d]pyrimidin-3-yl)-8-oxo-4,8-dihydro-1-thia-4,7a-diaza-s-indacene-7-carbonitrile

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1002/jhet.5570380217

upstream raw materials:

benzyl chloride

methyl 3-[3-(cyanomethyl)thioureido]thiophene-2-carboxylate

3-isothiocyanato-2-thiophenecarboxylic acid methyl ester