2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

Base Information

• Chemical Name: 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole
• CAS No.: 171523-08-3
• Molecular Formula: C₂₆H₂₃NO₄S
• Molecular Weight: 445.539
• Mol file: 171523-08-3.mol

Synonyms:2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

Chemical Property of 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

There total 2 articles about 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-methoxybenzoyl)-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole (171523-07-2) → 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole (171523-08-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(95)00704-C

Reference yield:

2,5-bis<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole (171523-06-1) → 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole (171523-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / HgO, 35percent aq. HBF₄ / tetrahydrofuran / Ambient temperature

2: 93 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium tetrahydroborate; tetrafluoroboric acid; mercury(II) oxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/0040-4020(95)00704-C

Reference yield: 53.0%

2-<2-(p-tolyl)-1,3-benzoxathiolyl>pyrrole + 2-<α-hydroxy-4-methoxybenzyl>-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole (171523-08-3) → 1-<2-(p-tolyl)-1,3-benzoxathiolyl>-5-(p-methoxyphenyl)-9-<2-(p-methoxyphenyl)-1,3-benzoxathiolyl>dipyrromethane (171523-10-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/0040-4020(95)00704-C

upstream raw materials:

2-(4-methoxybenzoyl)-5-<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

2,5-bis<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

Downstream raw materials:

1-<2-(p-tolyl)-1,3-benzoxathiolyl>-5-(p-methoxyphenyl)-9-<2-(p-methoxyphenyl)-1,3-benzoxathiolyl>dipyrromethane