3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE

Base Information

• Chemical Name: 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE
• CAS No.: 402-26-6
• Molecular Formula: C₇H₄BrF₃Mg
• Molecular Weight: 249.313
• Mol file: 402-26-6.mol

Synonyms:

Chemical Property of 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): 3
• Hazard Codes: 3

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE

There total 2 articles about 3-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-1-trifluoromethylbenzene (401-78-5) → 3-(trifluoromethyl)phenylmagnesium bromide (402-26-6)

Guidance literature:

With magnesium; In diethyl ether; at 20 ℃; for 2.53333 - 2.55h;

Reference yield:

3-bromo-1-trifluoromethylbenzene (401-78-5) + magnesium (7439-95-4) → 3-(trifluoromethyl)phenylmagnesium bromide (402-26-6)

Guidance literature:

In tetrahydrofuran; for 18h; Heating / reflux;

Reference yield: 99.0%

3-(trifluoromethyl)phenylmagnesium bromide (402-26-6) + phenyldimethylsilyl chloride (768-33-2) → dimethyl(phenyl)(3-(trifluoromethyl)phenyl)silane (1006715-22-5)

Guidance literature:

3-(trifluoromethyl)phenylmagnesium bromide; phenyldimethylsilyl chloride; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 3h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; 1,4-dioxane; Inert atmosphere;

DOI:10.1021/jo802433t

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

magnesium

Downstream raw materials:

2-[3-(trifluoromethyl)phenyl]ethanol

2-[1-(3-trifluoromethyl-phenyl)-vinyl]-thiophene

diphenyl(3-(trifluoromethyl)phenyl)methanol

dichloromethylsilane

Refernces

• 1、 Chong, Eugene,Kampf, Jeff W.,Ariafard, Alireza,Canty, Allan J.,Sanford, Melanie S.. "Oxidatively Induced C-H Activation at High Valent Nickel". supporting information. p. 6058 - 6061. Retrieved 2017/05/09.
• 2、 Nakatani, Jiro,Nozoe, Tatsuhiro. "Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones". . p. 1633 - 1636. Retrieved 2016/09/23.