N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Base Information

Chemical Name:N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine
CAS No.:913645-93-9
Molecular Formula:C₃₂H₃₈N₆O₇S₂
Molecular Weight:682.822
Hs Code.:

N<sup>2</sup>-isobutyryl-O<sup>6</sup>-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Synonyms:N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Suppliers and Price of N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

There total 6 articles about N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: diphenyl-carbamic acid 9-(3-tert-butyldisulfanylmethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-isobutyrylamino-9H-purin-6-yl ester

: 913645-93-9
N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja0636587

Reference yield:

: 64350-24-9
N²-isobutyryl-2'-deoxyguanosine

: 913645-93-9
N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 3.5 h / 20 °C

2.1: AcOH; Ac₂O / 24 h / 20 °C

2.2: K₂CO₃; water

3.1: 3 Angstroem MS; SO₂Cl₂; cyclohexene / CH₂Cl₂ / 1 h

3.2: CH₂Cl₂; dimethylformamide / 0.5 h / 20 °C

4.1: 24.92 g / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

5.1: N,N-diisopropylethylamine / pyridine / 2 h / 20 °C

6.1: 1.79 g / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With pyridine; sulfuryl dichloride; 3 Angstroem MS; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; N-ethyl-N,N-diisopropylamine; cyclohexene; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0636587

Reference yield:

: 913645-92-8
N²-isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(tert-butyldithiomethyl)guanosine

: 913645-93-9
N²-isobutyryl-O⁶-diphenylcarbamoyl-2'-O-(tert-butyldithiomethyl)guanosine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / pyridine / 2 h / 20 °C

2: 1.79 g / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/ja0636587