Technology Process of 1-methyl-3-phenyl-1H-indole-6-carboxylic acid
There total 6 articles about 1-methyl-3-phenyl-1H-indole-6-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 1-methyl-3-phenyl-1H-indole-6-carboxylate;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
for 4h;
With
citric acid;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / toluene / 4.03 h / 20 - 90 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 3 h
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
3.2: 1 h / 0 °C
4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; water; sodium hydride; trifluoroacetic acid; lithium hydroxide;
palladium diacetate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / toluene / 4.03 h / 20 - 90 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 3 h
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
3.2: 1 h / 0 °C
4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; water; sodium hydride; trifluoroacetic acid; lithium hydroxide;
palladium diacetate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
