triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Base Information

• Chemical Name: triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane
• CAS No.: 1300750-09-7
• Molecular Formula: C₃₁H₄₃NO₄SSi
• Molecular Weight: 553.838
• Mol file: 1300750-09-7.mol

Synonyms:triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Chemical Property of triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

There total 4 articles about triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1-en-7-yn-3-one (1300749-94-3) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane (1300750-09-7) + triisopropyl[(1E,3E)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.201003019

Reference yield:

C14H20OSi → triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane (1300750-09-7) + triisopropyl[(1E,3E)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrahydrofuran / Inert atmosphere

2: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

3: lithium diisopropyl amide / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/chem.201003019

Reference yield:

3-methyl-4-phenyl-3-buten-2-one (1901-26-4) → triisopropyl[(1E,3Z)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane (1300750-09-7) + triisopropyl[(1E,3E)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1,3-dien-7-yn-3-yloxy]silane

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/chem.201003019

upstream raw materials:

(E)-1-bromo-3-methyl-4-phenylbut-3-en-2-one

N-(but-2-yn-1-yl)-4-methoxybenzenesulfonamide

(E)-5-(p-methoxybenzenesulfonyl)-2-methyl-1-phenyl-5-azanona-1-en-7-yn-3-one

triisopropylsilyl trifluoromethanesulfonate