C₂₀H₃₀O₄

Base Information

• Chemical Name: C₂₀H₃₀O₄
• CAS No.: 1354575-76-0
• Molecular Formula: C₂₀H₃₀O₄
• Molecular Weight: 334.456
• Mol file: 1354575-76-0.mol

Synonyms:C₂₀H₃₀O₄

Chemical Property of C₂₀H₃₀O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₃₀O₄

There total 17 articles about C₂₀H₃₀O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C20H29IO4 (1354575-75-9) → C20H30O4 (1354575-76-0)

Guidance literature:

C₂₀H₂₉IO₄; With sodium iodide; zinc; In methanol; at 90 ℃; for 2.5h; Inert atmosphere;

With water; In methanol; Inert atmosphere;

DOI:10.1038/ja.2011.90

Reference yield:

(E)-7-((tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-1-ol (1310814-64-2) → C20H30O4 (1354575-76-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: trimethylamine hydrochloride; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium iodide / acetone / 8.5 h / Inert atmosphere; Reflux

3.1: tert.-butyl lithium / diethyl ether; pentane / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C / Inert atmosphere

3.3: 0 °C / Inert atmosphere

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere; Molecular sieve

5.1: pyridinium p-toluenesulfonate / methanol / 5 h / 20 °C / Inert atmosphere

6.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane / 18 h / -20 °C / Molecular sieve; Inert atmosphere

6.2: -20 °C / Inert atmosphere

7.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran; acetonitrile / 0 - 20 °C / Inert atmosphere

8.1: sodium iodide; zinc / methanol / 2.5 h / 90 °C / Inert atmosphere

8.2: Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; tetrapropylammonium perruthennate; diethyl (2R,3R)-tartrate; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; sodium iodide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; acetonitrile; pentane; 6.1: Sharpless asymmetric epoxidation;

DOI:10.1038/ja.2011.90

Reference yield:

C18H36O3Si → C20H30O4 (1354575-76-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

2.1: trimethylamine hydrochloride; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: sodium iodide / acetone / 8.5 h / Inert atmosphere; Reflux

4.1: tert.-butyl lithium / diethyl ether; pentane / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 0 °C / Inert atmosphere

4.3: 0 °C / Inert atmosphere

5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere; Molecular sieve

6.1: pyridinium p-toluenesulfonate / methanol / 5 h / 20 °C / Inert atmosphere

7.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane / 18 h / -20 °C / Molecular sieve; Inert atmosphere

7.2: -20 °C / Inert atmosphere

8.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran; acetonitrile / 0 - 20 °C / Inert atmosphere

9.1: sodium iodide; zinc / methanol / 2.5 h / 90 °C / Inert atmosphere

9.2: Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; tetrapropylammonium perruthennate; diethyl (2R,3R)-tartrate; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; sodium iodide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; acetonitrile; pentane; 7.1: Sharpless asymmetric epoxidation;

DOI:10.1038/ja.2011.90

upstream raw materials:

(E)-7-((tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-1-ol

C₁₃H₁₈O₃

(R)-2-((4-methoxybenzyl)oxy)-2-methylbutanal

C₁₃H₂₄O₅S

Downstream raw materials:

(3S,9R)-9-((4-methoxybenzyl)oxy)-9-methyl-8-oxoundec-1-en-3-yl acrylate