Technology Process of methyl 4-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoate
There total 7 articles about methyl 4-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
at 120 ℃;
for 6h;
DOI:10.1016/j.bmc.2006.01.062
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 12 percent / cesium carbonate; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / palladium(II) acetate / toluene / 7 h / 90 - 100 °C
2: triethylamine / CH2Cl2 / 0.17 h / 20 °C
3: sodium azide / dimethylformamide / 14 h / 80 °C
4: 288 mg / hydrogen / Pd/C / dioxane; H2O / 10 h / 20 °C
5: 67 percent / ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C
With
sodium azide; hydrogen; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal; palladium diacetate;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.01.062
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / CH2Cl2 / 0.17 h / 20 °C
2: sodium azide / dimethylformamide / 14 h / 80 °C
3: 288 mg / hydrogen / Pd/C / dioxane; H2O / 10 h / 20 °C
4: 67 percent / ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C
With
sodium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.062
