1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one

Base Information

Chemical Name:1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one
CAS No.:1026723-62-5
Molecular Formula:C₁₈H₁₉NO
Molecular Weight:265.355
Hs Code.:
DSSTox Substance ID:DTXSID301157287

Synonyms:SCHEMBL14903002;DTXSID301157287;1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one;1026723-62-5

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:265.146664230
Heavy Atom Count:20
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC2=C(N1C3=CC=CC=C3)CCC(C2=O)CC=C

Technology Process of 1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one

There total 4 articles about 1,5,6,7-Tetrahydro-2-methyl-1-phenyl-5-(2-propen-1-yl)-4H-indol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 72211-20-2
2-methyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one

: 106-95-6
allyl bromide

: 1026723-62-5
5-allyl-2-methyl-1-phenyl-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: 2-methyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; at 20 ℃;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 90534-62-6
2-(2-oxopropyl)cyclohexane-1,3-dione

: 1026723-62-5
5-allyl-2-methyl-1-phenyl-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / glacial acetic acid / 18 h / Heating

2: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 1 h

With acetic acid; lithium diisopropyl amide;
DOI:10.1002/jhet.5570350315

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 1026723-62-5
5-allyl-2-methyl-1-phenyl-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 24 h / 20 °C

2.1: acetic acid / 3 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 20 °C

With sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol;