Technology Process of dimethyl (1-acetamido-2-hydroxy-2-(p-tolyl)ethyl)phosphonate
There total 4 articles about dimethyl (1-acetamido-2-hydroxy-2-(p-tolyl)ethyl)phosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine);
In
methanol;
at 50 ℃;
for 24h;
under 7500.75 Torr;
Overall yield = 97.8 %; Overall yield = 294.5 mg; enantioselective reaction;
Schlenk technique;
Autoclave;
DOI:10.1021/ol303105d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: zinc; acetic acid / 5 h / 20 °C / Inert atmosphere
2: dichloro(benzene)ruthenium(II) dimer; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); cerium(III) chloride heptahydrate; hydrogen / methanol / 24 h / 50 °C / 7500.75 Torr / Schlenk technique; Autoclave
With
dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; acetic acid; zinc; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine);
In
methanol;
DOI:10.1021/ol303105d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium acetate / methanol; water / 2.17 h / 0 - 50 °C / Inert atmosphere
2: zinc; acetic acid / 5 h / 20 °C / Inert atmosphere
3: dichloro(benzene)ruthenium(II) dimer; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); cerium(III) chloride heptahydrate; hydrogen / methanol / 24 h / 50 °C / 7500.75 Torr / Schlenk technique; Autoclave
With
dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; sodium acetate; acetic acid; zinc; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine);
In
methanol; water;
DOI:10.1021/ol303105d