(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

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Chemical Name:(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid
CAS No.:583866-44-8
Molecular Formula:C₃₃H₃₅N₄O₆P
Molecular Weight:614.638
Hs Code.:

Synonyms:(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

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Chemical Property of (2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

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Technology Process of (2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

There total 1 articles about (2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5022-65-1
L-tryptophanamide hydrochloride

: 2-{[((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]methyl}pent-4-ynoic acid

: (2R)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

: 583866-44-8
(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1002/chem.200204456

Reference yield: 78.0%

: 51873-98-4,57207-34-8,24091-02-9
2-naphthaldoxime

: 583866-44-8
(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

: (2S)-3-{[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}-2-{[3-(2-naphthyl)isoxazol-5-yl]methyl}-3-oxopropyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

Guidance literature:: 2-naphthaldoxime; With pyridine; N-chloro-succinimide; In dichloromethane; at 20 - 45 ℃;

(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid; With triethylamine; In dichloromethane; at 45 ℃; Further stages.;
DOI:10.1002/chem.200204456

Reference yield: 76.0%

: 74482-46-5
3-phenoxybenzaldehyde oxime

: 583866-44-8
(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

: (2S)-3-{[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}-3-oxo-2-{[3-(3-phenoxyphenyl)isoxazol-5-yl]methyl}propyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid

Guidance literature:: 3-phenoxybenzaldehyde oxime; With pyridine; N-chloro-succinimide; In dichloromethane; at 20 - 45 ℃;

(2S)-2-({[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)pent-4-ynyl ((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)phosphinic acid; With triethylamine; In dichloromethane; at 45 ℃; Further stages.;
DOI:10.1002/chem.200204456