1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

Base Information

Chemical Name:1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea
CAS No.:1574312-11-0
Molecular Formula:C₁₇H₁₉F₃N₄O₂S₂
Molecular Weight:432.491
Hs Code.:

Synonyms:1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

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Chemical Property of 1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

Chemical Property:

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Technology Process of 1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

There total 4 articles about 1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448529-64-3
2-(difluoromethyl)-1-fluoro-4-isothiocyanato-benzene

: 1574312-10-9
6-(aminomethyl)-N-isopropyl-pyridine-3-sulfonamide

: 1574312-11-0
1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

Guidance literature:: In toluene; at 120 ℃; for 12h;

Reference yield:

: 1574312-08-5
6-cyano-N-isopropyl-pyridine-3-sulfonamide

: 1574312-11-0
1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: nickel / methanol / 12 h / 50 °C / 2585.81 Torr / Autoclave; Inert atmosphere

2: toluene / 12 h / 120 °C

With nickel; In methanol; toluene;

Reference yield:

: 64614-94-4
6-chloro-N-isopropyl-pyridine-3-sulfonamide

: 1574312-11-0
1-[3-(difluoromethyl)-4-fluoro-phenyl]-3-[[5-(isopropylsulfamoyl)-2-pyridyl]methyl]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 1,1' bis(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 2 h / 25 - 60 °C / Inert atmosphere

2: nickel / methanol / 12 h / 50 °C / 2585.81 Torr / Autoclave; Inert atmosphere

3: toluene / 12 h / 120 °C

With 1,1' bis(diphenylphosphino)ferrocene; palladium diacetate; nickel; In methanol; N,N-dimethyl acetamide; toluene;